Modern Pharmaceutics, Fifth Edition, Volume 2: Applications by Alexander T. Florence, Juergen Siepmann

By Alexander T. Florence, Juergen Siepmann

Quantity 2 discusses the purposes and methods in complicated drug supply platforms, together with transdermal, pulmonary, and ocular routes. moreover, it describes the impression of the shift to personalised medicinal drugs within the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology.DELIVERY of gear by means of THE PULMONARY path - Covers the interplay among the actual chemistry of the formulations and administered debris with the anatomy of the bronchial and alveolar regionsPEDIATRIC AND GERIATRIC PHARMACEUTICS - Addresses the physiological alterations, layout, and creation of formulations for every of those sufferer populationsBIOEQUIVALENCE evaluate - Covers tips on how to degree the bioequivalence of a similar drug in quick-release pill, tablet, or sustained-release shape, in addition to branded and favourite systemsTARGET-ORIENTED supply structures - Explores the demanding situations of designing supply structures that focus on particular websites within the physique and reason fewer unintended effects via interplay with non-diseased tissues

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59. Brem H, Ewend MG, Piantadosi S, et al. The safety of interstitial chemotherapy with BCNUloaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial. J Neurooncol 1995; 26:111–123. 60. Moses MA, Brem H, Langer R. Advancing the field of drug delivery taking aim at cancer. Cancer Cell 2003; 4:337–341. 61. Green SB, Byar DP, Walker MD, et al. Comparisons of carmustine; procarbazine; and highdose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

Brem H, Mahaley MS, Vick NA, et al. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 1991; 74:441–446. 57. Grossman SA, Reinhard C, Colvin OM, et al. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J Neurosurg 1992; 76:640–647. 58. Brem H, Piantadosi S, Burger PC, et al. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas.

In addition, the increase in the cost of the investigations of HV drugs—with usually wide therapeutic indices (35,38)—may result in difficulties in the development of new or generic drug products. In the case where the upper limit of the 90% CI (equation 4) falls exactly on the upper preset BE limit, Diff becomes equal to Diffmax, which is the maximum acceptable difference between means (25,39). Diffmax, and therefore the maximum acceptable geometric mean ratio (GMRmax) [GMRmax ¼ exp(Diffmax)], for a given 26 Macheras et al.

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