By Alexander T. Florence, Juergen Siepmann
With over a hundred illustrations, quantity 1 addresses the middle disciplines of pharmaceutics (absorption, PK, excipients, capsule dosage types, and packaging), and explores the demanding situations and paradigms of pharmaceutics.Features: NEW demanding situations AND PARADIGMS IN PHARMACEUTICS - Explores basic examine in actual phenomena regarding dose-form layout at a time whilst a lot learn is organic in natureCOVERS NEW suggestions FOR IN VIVO IMAGING DOSE kinds - except Gamma scintigraphy, till lately there were few technique of following genuine time habit of formulations in vivoDETAILED clarification OF CHEMICAL KINETICS AND DRUG balance - comprises many drug structural diagrams to demonstrate issues coated within the textHOW top to hold OUT PREFORMULATION - Discusses methods for studying medicinal drugs and their actual chemistry ahead of designing the precise formulationsTHE newest IN POWDER know-how - Explains the clever use of powders in pharmaceutics
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Extra info for Modern Pharmaceutics, Fifth Edition, Volume 1: Basic Principles and Systems (Drugs and the Pharmaceutical Sciences, Volume 188)
These epithelial cells (or enterocytes) are columnar in shape, and the luminal cell membrane, upon which the microvilli reside, is called the apical cell membrane. Opposite this membrane is the basal (or basolateral) plasma membrane, which is separated from the lamina propria by a basement membrane. A sketch of this cell is shown in Figure 5. The primary function of the villi is absorption. The microvilli region has also been referred to as the striated or “brush” border. It is in this region where the process of absorption is initiated.
The goblet cells appear as white dots on the villus surface. (B) Photomicrograph of a single human duodenal villus illustrating surface coverage by microvilli and the presence of goblet cells (white areas) (magnification 2400Â). (C) Photomicrograph illustrating the microvilli of the small intestine of the dog (magnification 33,000Â). Source: From Ref. 6. Figure 4 Diagrammatic sketch of the small intestine illustrating the projection of the villi into the lumen (left) and the anatomic features of a single villus (right).
Major advances in this research area allowing for a better understanding of the underlying drug transport mechanisms have been achieved by the working groups of Nicholson (64) and of Haller and Saltzman (65,66). However, there is a significant need for comprehensive and mechanistic mathematical theories relating formulation and processing parameters of dose forms to the resulting drug concentrations at the site of action and the pharmacodynamic effects of the treatment. An often underestimated aspect when characterizing dose forms in vitro is the importance of the type of environment the systems are exposed to.