Chronic obstructive pulmonary disease by Calverley, Peter M. A

By Calverley, Peter M. A

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As diagnostic habits differ greatly between different geographical regions, the comparison of health statistics data between countries may be difficult or even impossible. In addition it seems that misclassification may underestimate the impact of COPD more than for conditions such as cancer or ischemic heart disease. 8 It is also a clinical impression that the fact that COPD develops slowly and without dramatic manifestations results in underdiagnosis and that dyspnea caused by COPD is interpreted as being caused by other conditions like heart disease or simply old age.

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Am J Respir Crit Care Med 1994;150:1646–52. 23. Thompson AB, Daughton D, Robbins GA, Ghafouri MA, Oehlerking M, Rennard MI. Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters. Am Rev Respir Dis 1989;140:1527–37. 24. Maestrelli P, Saetta M, Di Stefano A, et al. Comparison of leukocyte counts in sputum, bronchial biopsies and bronchoalveolar lavage. Am J Respir Crit Care Med 1995;152:1926–31. 25. Takanashi S, Hasegawa Y, Kanehira Y, et al.

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