Cannabinoids [Handbook of Experimental Pharmacology 168] by Roger G. Pertwee (Ed.), Roger G. Pertwee

By Roger G. Pertwee (Ed.), Roger G. Pertwee

The current booklet is a phenomenal precis of many features of cannabinoid learn. It presents present wisdom in regards to the pharmacology and healing strength of cannabinoids in addition to wisdom in regards to the pharmacology, body structure, and pathology of the endogenous cannabinoid structures. The chapters are written by way of scientists who've made or are nonetheless making significant contributions to the sector. This ebook could support generate novel rules on the right way to procedure the research of emotions.

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2001). They found paired-pulse depression in the CA1 region of rat hippocampal slices to be increased both by anandamide and by two other TRPV1 receptor agonists, capsaicin and resiniferatoxin, in a manner that was sensitive to antagonism by capsazepine but not by the CB1 receptor antagonist AM281. Given the results obtained by Hájos et al. (see above), it is possible that these agonists were acting through central vanilloid-like receptors to cause a decrease in excitatory glutamatergic transmission.

1997). e. that palmitoylethanolamide acts through CB1 or TRPV1 receptors, can be ruled out. Thus, it produces antinociceptive effects that are not opposed by SR141716A (Calignano et al. 1998, 2001; Farquhar-Smith et al. 2002; Farquhar-Smith and Rice 2001) and it has been found not to attenuate nociceptive behaviour induced in mice by intraplantar injection of capsaicin (Calignano et al. 2001). Also, palmitoylethanolamide does not bind to or activate CB1 receptors at concentrations below 1 or 10 µM (Devane et al.

2000; Lambert et al. G. Pertwee Sheskin et al. 1997; Showalter et al. 1996), the antinociceptive effects of this fatty acid amide are opposed by SR144528. Evidence for CB2 -like receptors has also been obtained from experiments with the mouse vas deferens (Griffin et al. 1997). e. that palmitoylethanolamide acts through CB1 or TRPV1 receptors, can be ruled out. Thus, it produces antinociceptive effects that are not opposed by SR141716A (Calignano et al. 1998, 2001; Farquhar-Smith et al. 2002; Farquhar-Smith and Rice 2001) and it has been found not to attenuate nociceptive behaviour induced in mice by intraplantar injection of capsaicin (Calignano et al.

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