Biological Research on Addiction. Comprehensive Addictive by Peter M. Miller

By Peter M. Miller

Biological study on Addiction examines the neurobiological mechanisms of drug use and drug habit, describing how the mind responds to addictive elements in addition to the way it is plagued by medicines of abuse. The book's 4 major sections study behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.

This quantity is principally potent in providing present wisdom at the key neurobiological and genetic parts in an individual’s susceptibility to drug dependence, in addition to the approaches in which a few members continue from informal drug use to drug dependence.

Biological examine on Addiction is certainly one of 3 volumes comprising the 2,500-page sequence, Comprehensive Addictive Behaviors and Disorders. This sequence presents the main entire choice of present wisdom on addictive behaviors and problems up to now. briefly, it's the definitive reference paintings on addictions.

  • Each article offers thesaurus, complete references, steered readings, and a listing of internet resources
  • Edited and authored through the leaders within the box all over the world – the broadest, so much professional assurance available
  • Discusses the genetic foundation of addiction
  • Covers easy technological know-how study from quite a few animal studies

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Extra info for Biological Research on Addiction. Comprehensive Addictive Behaviors and Disorders, Volume 2

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The use of NHP is important to bridge the translational research gap between rodents and humans. Most alcohol research studies in NHPs have been completed in Old World monkey species, primarily cynomologus macaques, rhesus macaques, and baboons. NHPs are well suited for alcohol research involving complex experimental designs and long-term alcohol use because of their long life spans and adolescent period, which permit long-term, in-depth studies using the same subject as its own control. The use of a withinsubject design, in which each subject is exposed to each of the experimental conditions, is advantageous as it permits careful evaluation of individual differences and requires fewer subjects than conventional group designs to draw statistically significant, meaningful conclusions.

NONHUMAN PRIMATE MODELS OF ALCOHOL ABUSE AND ALCOHOLISM bolus IG infusions of alcohol (forced administration) did not facilitate subsequent acquisition of IG alcohol self-administration. Behavioral history, particularly experience with IV drug self-administration and high doses of alcohol (1–2 g kgÀ1 infusionÀ1), was necessary to establish IG alcohol self-administration. 5 g kgÀ1 and showed behavioral signs of physical dependence on termination of IG alcohol access. After oral alcohol consumption has been established and maintained using an induction procedure (see above), NHP will reliably self-administer alcohol orally over concentrations ranging from 2 to 32% w/v under limited access conditions (2–3 h sessions).

Markedly diminished effect with continued use of the same amount of alcohol 7. Withdrawal, as manifested by either of the following: a. Alcohol (or closely related substance) is taken to relieve or avoid withdrawal symptoms. b. Characteristic alcohol withdrawal syndrome defined as the presence of two or more of the following symptoms on cessation of alcohol: i. ii. iii. iv. v. vi. vii. viii. g. increased pulse rate or sweating) Nausea/vomiting Transient visual, tactile, or auditory hallucinations Psychomotor agitation Grand mal seizures Persons that meet criteria for alcohol dependence can be further grouped as follows: a.

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